UNC926 hydrochloride ( —— )

产品货号. M23797 CAS No. 1782573-49-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

UNC926 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

UNC926 盐酸盐是一种甲基赖氨酸 (Kme) 读取结构域抑制剂。
产品描述

UNC926 hydrochloride is a?methyl-lysine (Kme) reader domain?inhibitor.
体外实验

UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.
体内实验

——
同义词

——
通路

Chromatin/Epigenetic
靶点

Epigenetic Reader Domain
受体

L3MBTL1|L3MBTL3|L3MBTL4
研究领域

——
适应症

——

1.Herold JM, et al. Structure-activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45-51.

计算器

产品手册

关联产品

Escitalopram Oxalate

Escitalopram Oxalate 是一种选择性血清素 (5-HT) 再摄取抑制剂 (SSRI)，Ki 为 0.89 nM。
GSK778 hydrochloride

GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 hydrochloride hydrochloride phenocopies the effects of pan-BET inhibitors in cancer models.
UMB298

UMB298 是一种有效的选择性 CBP/P300 bromodomain 抑制剂。 UMB298 抑制 BRD4，IC50 为 5193nM。